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Anti-IL5 Treatments Compared in Patients With Severe Eosinophilic Asthma
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A novel dimer configuration revealed by the crystal structure at 2. Nature Human interleukin-5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein. FEBS Lett. Contributing signatures Signatures from InterPro member databases are used to construct an entry.
The best invention since the ELISA !
Unlike other members of this cytokine family namely interleukin 3 and GM-CSF , this glycoprotein in its active form is a homodimer. The IL-5 gene is located on chromosome 11 in the mouse, and chromosome 5 in humans, in close proximity to the genes encoding IL-3 , IL-4 , and granulocyte-macrophage colony-stimulating factor GM-CSF ,   which are often co-expressed in TH2 cells. Interleukin-5 is also expressed by eosinophils  and has been observed in the mast cells of asthmatic airways by immunohistochemistry.
Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma , wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Drugs that target IL-5 are mepolizumab and reslizumab. Eosinophils are terminally differentiated granulocytes found in most mammals.
The principal role of these cells, in a healthy host, is the elimination of antibody bound parasites through the release of cytotoxic granule proteins.
In fact, IL-5 was originally discovered as an eosinophil colony-stimulating factor,  is a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to survival. Mepolizumab is a monoclonal antibody against IL-5 which can reduce excessive eosinophilia.
IL5 - Interleukin-5 precursor - Homo sapiens (Human) - IL5 gene & protein
In Hodgkin lymphoma , for instance, the typically-observed eosinophilia is thought to be attributable to an increased production of IL Interleukin 5 has been shown to interact with Interleukin 5 receptor alpha subunit. From Wikipedia, the free encyclopedia.
Chromosome 5 human . National Center for Biotechnology Information, U. National Library of Medicine.